What diseases is sulfasalazine used to treat?
Sulfasalazine is used to treat rheumatoid arthritis, inflammatory bowel disease, as well as spondyloarthritis. The mechanism of action for treating rheumatoid arthritis is still unknown.
What is the usual dose of this medication?
The usual dose ranges from 2–3 grams daily, according to a twice-daily dosing schedule. Treatment can be started at 1 gram per day and then increased based on tolerability.
How long does sulfasalazine take to work?
Sulfasalazine does not work immediately. It may take at least 12 weeks for the first signs of improvement to appear.
Is there a need for blood tests while taking this medication?
Yes, a blood test is recommended two weeks after starting the medication and then once every month, to ensure the drug does not affect liver and kidney function.
What are the possible side effects?
Sulfasalazine may cause hypersensitivity and allergic reactions in patients who have reactions to sulfa drugs.
Mild gastrointestinal problems are common, but can be reduced by taking the drug with meals.
Patients should be screened for glucose-6-phosphate dehydrogenase (G6PD) deficiency before using sulfasalazine, as this deficiency may predispose them to red blood cell breakdown and anemia.
Blood tests are usually performed every 1–3 months depending on the dose.
