Gold is an effective medication for treating rheumatoid arthritis and is administered intramuscularly. Two formulations are available for injection: Myochrysine and Solganal.
What is the effect of Gold in treating rheumatoid arthritis?
A number of mechanisms have been proposed to explain the effect of Gold, but its mechanism of action in treating rheumatoid arthritis remains unknown.
What is the recommended dose of Gold?
The initial dose of Gold is 10 mg intramuscularly, followed by 25 mg in the second week, then 50 mg weekly until a response is achieved or until a cumulative dose of 1 gram is reached. If a positive response occurs, the dose is reduced to 50 mg every two weeks for 3 months, then every three weeks for another 3 months, and then continued as a monthly dose.
How long does it take for Gold to show its effect in the body?
Results are achieved within 4 to 6 months or after receiving 1 gram of the medication.
What are the possible side effects of Gold?
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Rash is the most common reaction following Gold administration. This rash can range from simple erythematous patches with itching to severe exfoliative dermatitis.
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Ulceration and inflammation of the mucous membranes of the mouth, tongue, and pharynx.
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More than 10% of patients experience mild proteinuria (protein leakage into the urine) due to gold-induced kidney disease.
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Immune thrombocytopenia, agranulocytosis, and aplastic anemia may occur rarely but are indicators that necessitate discontinuation of Gold.
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Muscle and joint pain after a Gold dose; consult your doctor if the pain is severe.
Should I have blood tests?
Before each Gold injection, the patient should have a complete blood count and a urinalysis to check protein levels in the urine.
Are there concerns about long-term use of Gold?
Long-term use of Gold may cause blue-gray skin discoloration, which is an expected side effect.
Gold during pregnancy and breastfeeding:
There are no studies on the effects of Gold during pregnancy and breastfeeding. It is recommended to inform your doctor if you wish to become pregnant.
