What is Azathioprine (Imuran)?
Azathioprine is an immunosuppressive medication.
What conditions require taking Azathioprine?
Azathioprine is used as a treatment for patients with rheumatoid arthritis who have not responded to other types of medications (for example, non-steroidal anti-inflammatory drugs such as ibuprofen). Rheumatoid arthritis occurs because the immune system attacks the joints. For cases of rheumatoid arthritis detected at an early stage, it is treated with intensive doses of Azathioprine, which helps reduce further joint damage and maintains joint function. This medication may also be used, as determined by the doctor, to treat systemic lupus erythematosus (lupus), to prevent the immune system from rejecting transplanted organs, to treat a certain type of inflammatory bowel disease (Crohn’s disease) that does not respond to conventional treatments, and to treat other immune system problems (autoimmune diseases).
How is Azathioprine taken?
Azathioprine is taken by mouth and is usually taken once daily according to the doctor’s instructions. Azathioprine should be taken with food to reduce stomach upset. The dose is determined based on the patient’s health condition, weight, and response to treatment.
What is the usual dose of Azathioprine?
The usual starting dose is 50 to 100 mg per day (one to two tablets).
What are the contraindications for Azathioprine?
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Patients who are allergic to Azathioprine.
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Pregnant women, women planning to become pregnant, or breastfeeding women.
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Some patients with liver disease, kidney disease, or blood disorders.
What are the possible side effects of Azathioprine?
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Nausea, vomiting, and diarrhea.
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Skin rash – may be accompanied by itching.
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Fever and general feeling of malaise.
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Rarely, Azathioprine may increase liver enzyme levels. This can be managed by monthly blood tests to monitor enzymes.
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Azathioprine can cause a decrease in red blood cell counts, white blood cell counts, and platelets (which help stop bleeding).
Should blood tests be done regularly while taking Azathioprine?
Yes, a blood test should be done every month.
