What diseases is Sulfasalazine used to treat?
Sulfasalazine is used to treat rheumatoid arthritis, inflammatory bowel disease, as well as spondyloarthritis. The mechanism of action for treating rheumatoid arthritis is still unknown.
What is the usual dose of this medication?
The usual dose ranges from 2-3 grams daily according to a twice-daily dosing regimen. Treatment can be started at 1 gram per day and then increased based on tolerability.
How long does Sulfasalazine take to work?
Sulfasalazine does not work immediately. It may take at least 12 weeks for the first signs of improvement to appear.
Are blood tests needed while taking this medication?
Yes, a blood test is recommended 2 weeks after starting the medication and then once every month to ensure the medication is not affecting liver and kidney function. Blood tests are usually done every 1-3 months depending on the dose.
What are the possible side effects?
Sulfasalazine may cause hypersensitivity and allergic reactions in patients who have reactions to sulfa drugs. Mild gastrointestinal problems are common but can be reduced by taking the medication with meals. Patients should be screened for G6PD deficiency before using sulfasalazine, as this may predispose them to hemolytic anemia.
